Astropan D : No more Dyspepsia !

Astropan D Tablets

Astropan D 

Pantoprazole 40 mg + Domperidone 10 mg tablets

Indication and Dosage:

• The drug is prescribed mainly for
• Dyspepsia
• Gastro-esophageal Reflux Disease 
• Gastric and Peptic Ulcers
• Asscociated symptoms like Belching, Bloating, Nausea and Vomitting

Dosage in Adult: Per tablet/capsule contains pantoprazole 40 mg and domperidone 10 mg: 1 tablet/capsule once daily.

Administration:

May be taken with or without food. May be taken without meals for better absorption & to reduce GI discomfort.

Contraindications: 

Pantoprazole: Hepatic impairment; hypersensitivity. Domperidone: History of hypersensitivity to dimenhydrinate or related compounds; GI haemorrhage, obstruction and perforation, or after surgery, pregnancy.

Special Precautions:

Lactation. Pantoprazole: Not recommended in child <12 yrs. Long-term therapy may lead to bacterial overgrowth in the GIT. Domperidone: Increases serum prolactin levels resulting to galactorrhoea in females and gynaecomastia in males. Hypertensive crisis in patients with phaeochromocytoma.

Adverse Drug Reactions:

Pantoprazole: Diarrhoea, dizziness, pruritus, skin rashes, GIT infections; anaphylaxis, angioedema, chest pain, dyspnoea, erythema multiforme, gastroenteritis, hyperglycaemia, infection, Inj site reaction, jaundice, optic neuropathy, anterior ischaemia, pancreatitis, speech disorder. 

Domperidone: Headache, insomnia, nervousness, dizziness, thirst, lethargy, irritability, GI disturbances, hot flushes, mastalgia, galactorrhoea, gynaecomastia, menstrual irregularities, rash, pruritus, urticaria, stomatitis, conjunctivitis, urinary frequency, dysuria, oedema, palpitations, leg cramps, asthaenia, drug intolerance.

Drug Interactions:

Care should be exercised when domperidone is administered in combination with MAO inhibitors.

Mechanism of Action:

Pantoprazole acts by selectively inhibiting the H+/K+-ATPase enzyme in the secretory canaliculus of the stimulated parietal cell. Domperidone stimulates GI activity by acting as a competitive antagonist at dopamine D2-receptors.